Antimalarial peroxides

Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.

Dispiro-1,2,4,5-tetraoxanes 2-4 were synthesized as potential peroxide antimalarial drugs. They had curative activity against Plasmodium berghei in vivo at single doses of 320 and 640 mg/kg which confirms earlier unpublished data. Moreover, artemisinin (1) and 4 had equivalent ED50's against P. berghei in vivo in the multiple-dose Thompson test; neither showed any evidence of acute toxicity at ...

The quest for beryllium peroxides.

There is no experimental proof documented in the literature for the existence of any beryllium peroxide compound. All recent pertinent preparative attempts described in this work, using a range of beryllium salts with various peroxides as reagents under mild conditions, were equally unsuccessful. (1)H and (9)Be NMR investigations of aqueous solutions containing beryllium salts and hydrogen pero...

Peroxides and Peroxide Forming Compounds

Inorganic and organic peroxides, because of their exceptional reactivity and oxidative potential are widely used in research laboratories. This review is intended to serve as a guide to the hazards and safety issues associated with the laboratory use, handling, and storage of inorganic and organic peroxy-compounds and peroxide-forming compounds. The relatively weak oxygen-oxygen linkage (bond-d...

Organic Peroxides in Radical Synthesis Reactions

Antimalarial natural products: a review

Objective: Malaria is an infectious disease commonplace in tropical countries. For many years, major antimalarial drugs consisted of natural products, but since 1930s these drugs have been largely replaced with a series of synthetic drugs. This article tries to briefly indicate that some plants which previously were used to treat malaria, as a result of deficiencies of synthetic drugs, have rev...